Substitutos ósseo sintético . Synthetic bone substitutes . Sustitutos óseos sintéticos
BonAlive Putty®* is a bioactive, osteoconductive and synthetic** osteostimulative filling bone cavities, which is made of bioactive glass granules1 2 mixed with a small amount of spherical glass. It also contains a synthetic binder soluble in water, which is a mixture of polyethylene glycols (PEG) and glycerol. The binder acts as a temporary bonding agent bioactive glass. After implantation, the binder is absorbed leaving only the bioactive glass, allowing infiltration of the tissue between the beads have a number of beneficial properties.
* BonAlive® Putty was not found to inhibit bacterial growth.
** Not osteoinductive
Intended Use
BonAlive putty is indicated for bone cavities and spaces.
Bone formation BonAlive® Putty
A pre-clinical study in a bone defect in the tibia of a rabbit, showed that with BonAlive ® putty, the formation of new bone is already visible in the second week after implantation (Figure 1).
Histological findings in 4th and 8th weeks demonstrate that the new bone is formed similarly to BonAlive ® putty and BonAlive ® granules (Figure 2). The graft area was highly vascularized with dense bone formation and periosteal growth in both cases.
Note: only BonAlive® Granules have the bacterial growth inhibiting effect since BonAlive® Putty has not been verified to inhibit bacterial growth.
Figure 1. Histological section 2 weeks after BonAlive® putty implantation
Figure 2. Histological 80-100 μm-thick sections from the BonAlive® putty and BonAlive® granules grafted areas at 4 and 8 weeks
